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Food Funct. 2017 Mar 22;8(3):1254-1270. doi: 10.1039/c7fo00045f.

Transcriptomic analyses of the anti-adipogenic effects of oleuropein in human mesenchymal stem cells.

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Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Avda. Menéndez Pidal s/n, 14004 Córdoba, Spain. and CIBER de Fragilidad y Envejecimiento Saludable, Spain.
Dep. Genética, Universidad de Córdoba, Campus Rabanales C5-1-O1, 14071 Córdoba, Spain.
GenXPro, Altenhoferallee 3, 60438 Frankfurt Main, Germany.
Dep. Bioquímica y Biología Molecular, Campus Rabanales C6-1-E17, Campus de Excelencia Internacional Agroalimentario (ceiA3), Universidad de Córdoba, 14071 Córdoba, Spain and CIBER de Fragilidad y Envejecimiento Saludable, Spain.


Extra virgin olive oil has positive effects on health. Oleuropein is a polyphenolic compound present in olive-tree leaves, fruits (olives) and olive oil. It is responsible for the relevant organoleptic and biological properties of olive oil, including antiadipogenic properties. Thus, the effects of oleuropein on the adipogenesis of human bone-marrow mesenchymal stem cells were studied by transcriptomics and differential gene-expression analyses. Oleuropein could upregulate expression of 60% of adipogenesis-repressed genes. Besides, it could activate signaling pathways such as Rho and β-catenin, maintaining cells at an undifferentiated stage. Our data suggest that mitochondrial activity is reduced by oleuropein, mostly during adipogenic differentiation. These results shed light on oleuropein activity on cells, with potential application as a "nutraceutical" for the prevention and treatment of diseases such as obesity and osteoporosis.

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