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Development. 2017 Apr 15;144(8):1477-1483. doi: 10.1242/dev.143701. Epub 2017 Feb 27.

Stomach curvature is generated by left-right asymmetric gut morphogenesis.

Author information

1
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
2
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA nmnascon@ncsu.edu.

Abstract

Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric rotation of the intestine is directed by forces outside the gut, but the morphogenetic events that generate anatomical asymmetry in other regions of the digestive tract remain unknown. Here, we show in mouse and Xenopus that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement. These asymmetries exist across several species, and are dependent on LR patterning genes, including Foxj1, Nodal and Pitx2 Our findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts.

KEYWORDS:

Asymmetry; Gut; Left-right; Morphogenesis; Mouse; Pitx2; Stomach; Xenopus

PMID:
28242610
PMCID:
PMC5399665
DOI:
10.1242/dev.143701
[Indexed for MEDLINE]
Free PMC Article

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