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Brain Behav. 2017 Jan 3;7(2):e00613. doi: 10.1002/brb3.613. eCollection 2017 Feb.

Quantitative imaging biomarkers for dural sinus patterns in idiopathic intracranial hypertension.

Author information

1
Division of Ophthalmology Sackler Faculty of Medicine Tel Aviv Sourasky Medical Center Tel Aviv University Tel Aviv Israel.
2
Diagnostic Imaging Department Soroka University Medical Center Ben-Gurion University of the Negev Beer-Sheva Israel.
3
Zolotowsky Neuroscience Center Ben-Gurion University of the Negev Beer-Sheva Israel.
4
Clinical Research Center Soroka University Medical Center Ben-Gurion University of the Negev Beer-Sheva Israel.

Abstract

OBJECTIVE:

To quantitatively characterize transverse dural sinuses (TS) on magnetic resonance venography (MRV) in patients with idiopathic intracranial hypertension (IIH), compared to healthy controls, using a computer assisted detection (CAD) method.

MATERIALS AND METHODS:

We retrospectively analyzed MRV studies of 38 IIH patients and 30 controls, matched by age and gender. Data analysis was performed using a specially developed Matlab algorithm for vessel cross-sectional analysis. The cross-sectional area and shape measurements were evaluated in patients and controls.

RESULTS:

Mean, minimal, and maximal cross-sectional areas as well as volumetric parameters of the right and left transverse sinuses were significantly smaller in IIH patients than in controls (< .005 for all). Idiopathic intracranial hypertension patients showed a narrowed segment in both TS, clustering near the junction with the sigmoid sinus. In 36% (right TS) and 43% (left TS), the stenosis extended to >50% of the entire length of the TS, i.e. the TS was hypoplastic. Narrower vessels tended to have a more triangular shape than did wider vessels.

CONCLUSION:

Using CAD we precisely quantified TS stenosis and its severity in IIH patients by cross-sectional and volumetric analysis. This method can be used as an exact tool for investigating mechanisms of IIH development and response to treatment.

KEYWORDS:

MRI; idiopathic intracranial hypertension; neuro‐ophthalmology

PMID:
28239523
PMCID:
PMC5318366
DOI:
10.1002/brb3.613
[Indexed for MEDLINE]
Free PMC Article

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