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Semin Cell Dev Biol. 2017 Jun;66:36-42. doi: 10.1016/j.semcdb.2017.02.004. Epub 2017 Feb 24.

Mechanisms of embryonic stomach development.

Author information

1
Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: kyle.mccracken@childrens.harvard.edu.
2
Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Division of Endocrinology Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Electronic address: james.wells@cchmc.org.

Abstract

The stomach is a digestive organ that has important roles in human physiology and pathophysiology. The developmental origin of the stomach is the embryonic foregut, which also gives rise a number of other structures. There are several signaling pathways and transcription factors that are known to regulate stomach development at different stages, including foregut patterning, stomach specification, and gastric regionalization. These developmental events have important implications in later homeostasis and disease in the adult stomach. Here we will review the literature that has shaped our current understanding of the molecular mechanisms that coordinate gastric organogenesis. Further we will discuss how developmental paradigms have guided recent efforts to differentiate stomach tissue from pluripotent stem cells.

KEYWORDS:

Antrum; Corpus; Endoderm; Foregut; Fundus; Stomach

PMID:
28238948
PMCID:
PMC5474362
DOI:
10.1016/j.semcdb.2017.02.004
[Indexed for MEDLINE]
Free PMC Article

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