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Exp Cell Res. 2017 Mar 15;352(2):420-426. doi: 10.1016/j.yexcr.2017.02.038. Epub 2017 Feb 24.

Modulation of hepatic stellate cells and reversibility of hepatic fibrosis.

Author information

1
Faculty of Graduate Studies of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, PR China. Electronic address: 1293363632@QQ.com.
2
Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 East China Road, Nanning 530011, Guangxi Zhuang Autonomous Region, PR China. Electronic address: Hendly@163.com.
3
Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, PR China. Electronic address: lj99669@163.com.

Abstract

Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed. Over the past ten years, a number of studies have addressed this process, and here we present a review of HSC modulation and HF reversal.

KEYWORDS:

Hepatic fibrosis; Hepatic stellate cells; Mechanism; Modulation; Reversibility

PMID:
28238836
DOI:
10.1016/j.yexcr.2017.02.038
[Indexed for MEDLINE]

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