Format

Send to

Choose Destination
Methods Mol Biol. 2017;1570:279-285. doi: 10.1007/978-1-4939-6840-4_19.

Application of Hydrogel Template Strategy in Ocular Drug Delivery.

Author information

1
Ocular Nanomedicine Research Laboratory, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 77030, USA.
2
Industrial and Physical Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47906, USA.
3
Ocular Nanomedicine Research Laboratory, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 77030, USA. gacharya@bcm.edu.

Abstract

The hydrogel template strategy was previously developed to fabricate homogeneous polymeric microparticles. Here, we demonstrate the versatility of the hydrogel template strategy for the development of nanowafer-based ocular drug delivery systems. We describe the fabrication of dexamethasone-loaded nanowafers using polyvinyl alcohol and the instillation of a nanowafer on a mouse eye. The nanowafer, a small circular disk, is placed on the ocular surface, and it releases a drug as it slowly dissolves over time, thus increasing ocular bioavailability and enhancing efficiency to treat eye injuries.

KEYWORDS:

Cornea; Dexamethasone; Drug delivery; Eye; Hydrogel; Nanowafer

PMID:
28238144
DOI:
10.1007/978-1-4939-6840-4_19
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center