Over 10 years MRI observation of a patient with neuronal intranuclear inclusion disease

BMJ Case Rep. 2017 Feb 24:2017:bcr2016218790. doi: 10.1136/bcr-2016-218790.

Abstract

We present a sporadic neuronal intranuclear inclusion disease (NIID) patient with neuropathy followed by cognitive dysfunction along with brain MRIs findings of leucoencephalopathy. Her cognitive impairment gradually progressed along with abnormal intensity lesions in diffusion-weighted images. This pathological and clinical deterioration resemble pathological process in prion diseases.

Publication types

  • Case Reports

MeSH terms

  • Cognitive Dysfunction / etiology*
  • Diffusion Magnetic Resonance Imaging
  • Disease Progression
  • Female
  • Humans
  • Intranuclear Inclusion Bodies
  • Leukoencephalopathies / diagnostic imaging*
  • Leukoencephalopathies / etiology
  • Longitudinal Studies
  • Middle Aged
  • Neurodegenerative Diseases / complications
  • Neurodegenerative Diseases / diagnostic imaging*

Supplementary concepts

  • Neuronal intranuclear inclusion disease