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Med Clin (Barc). 2017 Jun 21;148(12):539-547. doi: 10.1016/j.medcli.2016.12.036. Epub 2017 Feb 22.

Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. A randomized, double-blind, placebo-controlled functional magnetic resonance imaging study.

[Article in English, Spanish]

Author information

1
Departamento de Reumatología, Hospital del Mar, Barcelona, España.
2
Unidad de Investigación en RM, Hospital del Mar, Cibersam G21, Barcelona, España. Electronic address: 21404jpn@comb.cat.
3
Unidad de Investigación en RM, Hospital del Mar, Cibersam G21, Barcelona, España.
4
Unidad de Investigación en RM, Hospital del Mar, Cibersam G21, Barcelona, España; Department of Psychology and Neuroscience. University of Colorado Boulder, Colorado, Estados Unidos.
5
Área de Investigación y Desarrollo Clínico, División de Farma-Ciencia, Bioibérica, Barcelona, España.
6
Centro de Atención Sanitaria Primaria Vila Olímpica (PAMEM), Barcelona, España.
7
Unidad de Investigación en RM, Hospital del Mar, Cibersam G21, Barcelona, España; Departamento de Psicología Clínica y Sanitaria, Universidad Autónoma de Barcelona, Barcelona, España.

Abstract

INTRODUCTION:

Knee osteoarthritis is causing pain and functional disability. One of the inherent problems with efficacy assessment of pain medication was the lack of objective pain measurements, but functional magnetic resonance imaging (fMRI) has emerged as a useful means to objectify brain response to painful stimulation. We have investigated the effect of chondroitin sulfate (CS) on brain response to knee painful stimulation in patients with knee osteoarthritis using fMRI.

METHODS:

Twenty-two patients received CS (800mg/day) and 27 patients placebo, and were assessed at baseline and after 4 months of treatment. Two fMRI tests were conducted in each session by applying painful pressure on the knee interline and on the patella surface. The outcome measurement was attenuation of the response evoked by knee painful stimulation in the brain.

RESULTS:

fMRI of patella pain showed significantly greater activation reduction under CS compared with placebo in the region of the mesencephalic periaquecductal gray. The CS group, additionally showed pre/post-treatment activation reduction in the cortical representation of the leg. No effects of CS were detected using the interline pressure test.

CONCLUSIONS:

fMRI was sensitive to objectify CS effects on brain response to painful pressure on patellofemoral cartilage, which is consistent with the known CS action on chondrocyte regeneration. The current work yields further support to the utility of fMRI to objectify treatment effects on osteoarthritis pain.

KEYWORDS:

Artrosis de rodilla; Chondroitin sulfate; Condroitín sulfato; Dolor; Functional magnetic resonance image; Knee osteoarthritis; Pain; Resonancia magnética funcional

PMID:
28237612
DOI:
10.1016/j.medcli.2016.12.036
[Indexed for MEDLINE]

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