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J Craniomaxillofac Surg. 2017 Apr;45(4):449-454. doi: 10.1016/j.jcms.2017.01.010. Epub 2017 Jan 25.

Comparison of intra-articular injection of plasma rich in growth factors versus hyaluronic acid following arthroscopy in the treatment of temporomandibular dysfunction: A randomised prospective study.

Author information

1
Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain. Electronic address: mfernandezf@povisa.es.
2
Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain.
3
School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.

Abstract

PURPOSE:

The main objective of our study was to evaluate the effectiveness of the injection of plasma rich in platelet-derived growth factors (PRGF) versus hyaluronic acid (HA) following arthroscopic surgery in patients diagnosed with internal derangement of the temporomandibular joint (TMJ) with osteoarthritis (OA).

MATERIALS AND METHODS:

A total of 100 patients were randomised into two study groups. Group A (n = 50) received an injection of PRGF, and Group B (n = 50) received an injection of HA. The mean age was 35.5 years (range 18-77 years), and 88% of the patients were women. The pain intensity (visual analogue scale) and the extent of maximum mouth opening before and after the procedure were statistically analysed.

RESULTS:

Better results were observed in the group treated with PRGF, with a significant reduction in pain at 18 months, compared with HA treatment. Regarding mouth opening, an increase was observed in both groups, with no significant difference.

CONCLUSIONS:

The injection of PRGF following arthroscopy is more effective than the injection of HA with respect to pain in patients with advanced internal derangement of the TMJ.

KEYWORDS:

Arthroscopy; Hyaluronic acid; Internal derangement; Osteoarthritis; Plasma rich in platelet-derived growth factors; Temporomandibular disorder

PMID:
28237253
DOI:
10.1016/j.jcms.2017.01.010
[Indexed for MEDLINE]

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