Format

Send to

Choose Destination
Prostaglandins Leukot Essent Fatty Acids. 2017 Feb;117:28-35. doi: 10.1016/j.plefa.2017.01.007. Epub 2017 Jan 25.

Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials.

Author information

1
Program in International and Community Nutrition, Department of Nutrition, University of California, 3135 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA. Electronic address: boaks@ucdavis.edu.
2
Program in International and Community Nutrition, Department of Nutrition, University of California, 3135 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.
3
Department of Nutrition and Food Science, University of Ghana, Legon, Ghana.
4
Center for Child Health Research, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland.
5
OmegaQuant Analytics, LLC, Sioux Falls, SD, USA.
6
University of Malawi College of Medicine, Department of Community Health, Blantyre, Malawi.
7
USDA, ARS Western Human Nutrition Research Center, Davis, CA, USA.
8
Center for Child Health Research, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland.

Abstract

It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids (wt%) at 6 months postpartum in a subsample of women enrolled in a randomized controlled trial studying the effects of SQ-LNS on birth outcomes and child growth. Women≤20 wk gestation in Ghana (n=1,320) and Malawi (n=1,391) were assigned to receive daily either: 1) iron-folic acid (pregnancy); 2) multiple micronutrients (pregnancy and lactation); or 3) SQ-LNS (pregnancy and lactation). At 36 wk, plasma ALA levels were higher in those receiving SQ-LNS. SQ-LNS increased breast milk ALA in Ghana but not Malawi. There was no effect on plasma lipids or other selected fatty acids. SQ-LNS may impact plasma and breast milk ALA levels depending on the population.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00970866 NCT01239693.

KEYWORDS:

Cholesterol; Lactation; Lipids; Omega-3 fatty acids; Pregnancy; Supplementation

PMID:
28237085
PMCID:
PMC5338685
DOI:
10.1016/j.plefa.2017.01.007
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center