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Ann Neurol. 1987 Sep;22(3):377-80.

Detection of varicella-zoster virus nucleic acid in neurons of normal human thoracic ganglia.

Author information

1
Department of Neurology, University of Colorado School of Medicine, Denver 80262.

Abstract

Tissue sections from four normal human thoracic ganglia were hybridized in situ with a varicella-zoster virus-RNA probe. Varicella-zoster virus was detected in two of four ganglia, localized exclusively in neurons. The detection of latent varicella-zoster virus genetic material in thoracic ganglia provides further evidence of varicella-zoster virus latency at multiple levels of the human neuraxis and supports the notion that the neuron is the primary site of herpesvirus latency.

PMID:
2823688
DOI:
10.1002/ana.410220315
[Indexed for MEDLINE]

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