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Med Hypotheses. 2017 Mar;100:78-81. doi: 10.1016/j.mehy.2017.01.018. Epub 2017 Jan 28.

In pursuit of cancer metastasis therapy by bacteria and its biofilms: History or future.

Author information

1
Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il, Ha'il, PO Box 2440, Saudi Arabia. Electronic address: drmohdadnan@gmail.com.
2
Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il, Ha'il, PO Box 2440, Saudi Arabia.
3
Bapalal Vaidhya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, Surat, Gujarat, India.
4
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Ha'il, Ha'il, PO Box 2440, Saudi Arabia.
5
School of Forensic and Applied Sciences, University of Central Lancashire, Preston, PR1 2HE, United Kingdom.

Abstract

The 20th century observation of increasing comprehensive load of cancer, advanced cancer prevention strategies, creative hypotheses and control procedures by research communities are being traversed and stimulated in multiple facets. Inference of genetically modified non-pathogenic and natural bacterial species as potential anti-tumor agents is one such original perspective. Live, genetically modified non-pathogenic or attenuated bacterial species are able to form biofilms by multiplying selectively or non-selectively on cancer cells, which will lead to metastasis disruption. However, the appearance of gene-directed prodrug therapy and recombinant DNA technology has invigorated the notice in range of applications employing bacteria and bacterial therapy and have been carried out. The most possible and promising upcoming strategies are bacteria mediated cancer treatment. Significant efficacy in pre-clinical studies have been demonstrated and some are presently under clinical investigation. The theorem is that cancer metastasis can either be blunt by opponent bacterial biofilm infection or serve as model vectors for delivering therapeutic proteins to tumors or generation of the new phenotypes during the SOS reaction incite by anticancer drugs.

KEYWORDS:

Anti-metastasis phenotypes; Bacteria mediated cancer therapy; Biofilms; Coley’s toxin; Metastasis

PMID:
28236853
DOI:
10.1016/j.mehy.2017.01.018
[Indexed for MEDLINE]

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