Format

Send to

Choose Destination
Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):913-921. doi: 10.1007/s00417-017-3588-y. Epub 2017 Feb 23.

Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography.

Author information

1
Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
2
Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany. dapauleikhoff@muenster.d.

Abstract

BACKGROUND:

With FA and SD-OCT, different types of CNV in exudative AMD may be differentiated: type 1 CNV (within the sub-RPE space, typically corresponding to angiographically occult CNV), type 2 CNV (within the subretinal space, typically corresponding to angiographically classic CNV) and type 3 NV (intraretinal retinal angiomatous proliferation). OCT-angiography (OCT-A) is a new method to visualize vasculature based on flow characteristics. A correlation of type 1 and 2 CNV was performed.

METHODS:

Thirty-six eyes (17 type 1 CNV, 9 combined type 1 and 2 CNV, and 10 type 2 CNV) of 36 patients were examined by FA, SD-OCT and OCT-A. Standardized OCT-A segmentations were performed at the level of mid-choroid, choriocapillaris (CC), RPE and outer retina. On these images the size and demarcation of CNV lesions were classified: "not distinguishable", "minor" or "sharp" demarcation. Furthermore, the size of the different CNV subtypes was determined and compared.

RESULTS:

Both types of CNV were visible in OCT-A. They could be detected on the slabs "mid-choroid", "CC" and "RPE". While type 1 CNV showed most often a minor demarcation from the surrounding vasculature, type 2 CNV showed nearly always a sharp demarcation. In addition, type 2 CNV extended into the slab "outer retina" and were much smaller than type 1 CNV.

CONCLUSIONS:

Different types of CNV in exudative AMD can be visualized and differentiated with OCT-A. Type 1 CNV were larger with minor demarcation from the surrounding vasculature and were visible on the slab "mid-choroid", "CC" and "RPE". In contrast, type 2 CNV demonstrated a sharp demarcation from the surrounding vasculature reaching the slab "outer retina".

KEYWORDS:

Choroidal neovascularisation; Exudative AMD; FA; Imaging analysis; OCT- angiography; Type 1 choroidal neovascularisation; Type 2 choroidal neovascularisation

PMID:
28233061
DOI:
10.1007/s00417-017-3588-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center