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Front Mol Neurosci. 2017 Feb 9;10:31. doi: 10.3389/fnmol.2017.00031. eCollection 2017.

Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.

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Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University Aarhus, Denmark.
Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands.
Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark Odense, Denmark.
Laboratory for Experimental Neuropathology, Department of Pathology, Randers Hospital Randers, Denmark.


The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.


brain development; cortical morphogenesis; embryonic development; miR-204; miR-34c; microRNA; neuronal migration

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