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Nat Genet. 2017 Feb 24;49(3):323-324. doi: 10.1038/ng.3798.

Untangling the genetics from the epigenetics in pancreatic cancer metastasis.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

Abstract

Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

PMID:
28232730
DOI:
10.1038/ng.3798
[Indexed for MEDLINE]

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