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Cancer Res Treat. 2018 Jan;50(1):11-18. doi: 10.4143/crt.2016.600. Epub 2017 Feb 24.

Evaluation of Diagnostic Performance of Screening Thyroid Ultrasonography and Imaging Findings of Screening-Detected Thyroid Cancer.

Author information

1
Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
2
Department of Radiology, New Korea Hospital/Human Medical Imaging and Intervention Center, Gimpo, Korea.
3
Department of Radiology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.

Abstract

PURPOSE:

The purpose of this study was to evaluate the diagnostic performance and cost of screening thyroid ultrasonography (US) in an asymptomatic population and determine the US features of screening-detected thyroid cancer.

MATERIALS AND METHODS:

This study included 1,845 asymptomatic participants who underwent screening thyroid US between March and August 2012 at the screening center in our hospital. We evaluated the diagnostic performance of screening thyroid US for thyroid cancer and the average cost of diagnosis for each patient. We also determined the characteristic US features of screening-detected thyroid cancer.

RESULTS:

Of the 1,845 subjects, 661 showed no abnormalities, 1,155 exhibited benign thyroid nodules, and 29 exhibited thyroid cancer. Imaging features such as solid composition, hypoechogenicity, taller-than-wide axis, and ill-defined or spiculated margins of nodules were suggestive of malignancy. The rate of detection of cancer was 1.6% (29/1,845), and the sensitivity, specificity, and positive and negative predictive values were 100% (18/18), 98.7% (1,051/1,065), 56.3% (18/32), and 100% (1,051/1,051), respectively. Of 18 patients who underwent thyroidectomy, three (16.7%) had a pathological tumor staging of T3, and four (22.2%) had a pathological nodal staging of N1a. The average cost of diagnosis for each patient with cancer was $7,319.

CONCLUSION:

Screening thyroid US exhibited a good diagnostic performance, with a feasible social cost of use. This modality demonstrated significant differences in sonographic features between screening-detected cancer and benign nodules.

KEYWORDS:

Costs and cost analysis; Diagnostic techniques and procedures; Thyroid neoplasms; Ultrasonography

PMID:
28231691
PMCID:
PMC5784632
DOI:
10.4143/crt.2016.600
[Indexed for MEDLINE]
Free PMC Article

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