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Environ Res. 2017 May;155:199-207. doi: 10.1016/j.envres.2017.02.018. Epub 2017 Mar 10.

Nonmonotonic responses to low doses of xenoestrogens: A review.

Author information

1
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, Yunnan, China.
2
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, Yunnan, China. Electronic address: huangbin@kmust.edu.cn.

Abstract

Xenoestrogens (XEs) mimic or block the synthesis, metabolism and transport of normal endogenous hormones, disturbing normal endocrine function. The available data on the nonmonotonic estrogenic effects of low doses of many XEs are reviewed, covering in vitro, in vivo and epidemiological studies. The observed nonmonotonic patterns of the dose-response curves are discussed, along with possible underlying mechanisms. This review is intended to provide guidance for harm predication and to suggest prevention measures.

KEYWORDS:

Dose-response effects; Molecular mechanisms; Nonmonotonic responses; Toxicology; Xenoestrogens

PMID:
28231547
DOI:
10.1016/j.envres.2017.02.018
[Indexed for MEDLINE]

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