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Neuron. 2017 Feb 22;93(4):747-765. doi: 10.1016/j.neuron.2017.01.014.

Neural Circuitry of Wakefulness and Sleep.

Author information

1
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Neurology, Boston Children's Hospital, Boston, MA 02215, USA. Electronic address: tscammel@bidmc.harvard.edu.
2
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
3
Department of Neurology, Boston Children's Hospital, Boston, MA 02215, USA; F.M. Kirby Neurobiology Center, Boston, MA 02215, USA.

Abstract

Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review current perspectives on the neural systems that regulate sleep/wake states in mammals and the circadian mechanisms that control their timing. We also outline key models for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.

KEYWORDS:

REM sleep; arousal; chemogenetics; circadian; hypocretin; monoamines; non-REM sleep; optogenetics; orexin; pharmacogenetics; wake

PMID:
28231463
PMCID:
PMC5325713
DOI:
10.1016/j.neuron.2017.01.014
[Indexed for MEDLINE]
Free PMC Article

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