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Medicine (Baltimore). 2017 Feb;96(8):e6159. doi: 10.1097/MD.0000000000006159.

Dengue-associated hemophagocytic lymphohistiocytosis in an adult: A case report and literature review.

Author information

1
aDivision of Infectious Disease, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul bDepartment of Internal Medicine, Konyang University College of Medicine, Daejeon cDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.

Abstract

BACKGROUND:

Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand.

CASE SUMMARY:

A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized.

CONCLUSION:

It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

PMID:
28225498
PMCID:
PMC5569431
DOI:
10.1097/MD.0000000000006159
[Indexed for MEDLINE]
Free PMC Article

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