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Adv Ther. 2017 Apr;34(4):813-825. doi: 10.1007/s12325-017-0494-y. Epub 2017 Feb 21.

How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?

Author information

1
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain. flopez_1981@yahoo.es.
2
Instituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo, Oviedo, Spain. flopez_1981@yahoo.es.
3
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
4
Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic.
5
Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
6
Instituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo, Oviedo, Spain.
7
Departments of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh, UK.
8
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
9
Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
10
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
11
Department of Otolaryngology, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
12
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
13
University of Udine School of Medicine, Udine, Italy.
14
Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Abstract

Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. The role of adjuvant radiotherapy has not been well defined, although there is an agreement that it should be considered in advanced-stage or high-grade disease. This review considers only the most common malignant salivary neoplasms of the larynx with a focus on clinical management of these tumors.

KEYWORDS:

Adenocarcinoma; Adenoid cystic carcinoma; Histology; Laryngeal cancer; Larynx mucoepidermoid carcinoma; Salivary gland carcinomas

PMID:
28224460
DOI:
10.1007/s12325-017-0494-y
[Indexed for MEDLINE]

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