Send to

Choose Destination
Sci Rep. 2017 Feb 22;7:43029. doi: 10.1038/srep43029.

High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease.

Author information

The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, Ibaraki, 305-8576, Japan.
Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan.
National Institute of Occupational Safety and Health, Kanagawa, 214-8585, Japan.
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.
Faculty of Sports Health Care, Inje University, Gyeongsangnamdo, 50834, Republic of Korea.
Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.


We compared the effects of 12-week programs of resistance training (RT), high-intensity interval aerobic training (HIAT), and moderate-intensity continuous aerobic training (MICT). The primary goal was to evaluate the therapeutic effects of the exercise modalities for the management of nonalcoholic fatty liver disease (NAFLD). A total of 61 sedentary obese men with NAFLD were randomized into one of the following exercise regimens (RT, HIAT, or MICT). Hepatic fat content was decreased to a similar extent in the RT, HIAT, and MICT groups (-14.3% vs. -13.7% vs. -14.3%) without significant changes in weight and visceral fat. The gene expression levels of fatty acid synthesis were significantly decreased in the subjects' monocytes. Hepatic stiffness was decreased only in the HIAT group (-16.8%). The stiffness change was associated with restored Kupffer cell phagocytic function (+17.8%) and decreased levels of inflammation such as leptin (-13.2%) and ferritin (-14.1%). RT, HIAT, and MICT were equally effective in reducing hepatic fat content, but only HIAT was effective in improving hepatic stiffness and restoring Kupffer cell function. These benefits appeared to be independent of detectable weight and visceral fat reductions; the benefits were acquired through the modulation of in vivo fatty acid metabolism and obesity-related inflammatory conditions.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center