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Clin Chem. 1987 Oct;33(10):1906-8.

Inhibitory effect of disulfiram (Antabuse) on alcohol dehydrogenase activity.

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1
Department of Psychiatry, Veteran's Administration Medical Center, Wichita, KS 67218.

Abstract

We investigated the effect of disulfiram (Antabuse) on the activity of alcohol dehydrogenase (EC 1.1.1.1) in vitro. We observed a time-dependent inhibition of this dehydrogenase by disulfiram and diethyldithiocarbamate similar to that obtained for aldehyde dehydrogenase (EC 1.2.1.3). These results suggest a possible explanation for various side effects observed in the clinical use of Antabuse.

PMID:
2822291
[Indexed for MEDLINE]
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