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Tumour Biol. 2017 Feb;39(2):1010428317691680. doi: 10.1177/1010428317691680.

Curcumin inhibits cancer progression through regulating expression of microRNAs.

Zhou S1,2, Zhang S3, Shen H2,4, Chen W5, Xu H1,6, Chen X2,4, Sun D2, Zhong S7, Zhao J7, Tang J1,2,8.

Author information

1
1 The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
2
2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.
3
3 Department of Breath Internal Medicine, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, China.
4
4 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.
5
5 Graduate School, Xuzhou Medical College, Xuzhou, China.
6
6 Department of Radiotherapy, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.
7
7 Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
8
8 Jiangsu Province Hospital, Nanjing, China.

Abstract

Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. It has been reported that microRNAs as small noncoding RNA molecules are related to cancer progression, which can be regulated by curcumin. Dysregulated microRNAs play vital roles in tumor biology via regulating expressions of target genes and then influencing multiple cancer-related signaling pathways. In this review, we focused on the inhibition effect of curcumin on various cancer progression by regulating expression of multiple microRNAs. Curcumin-induced dysregulation of microRNAs may activate or inactivate a set of signaling pathways, such as Akt, Bcl-2, PTEN, p53, Notch, and Erbb signaling pathways. A better understanding of the relation between curcumin and microRNAs may provide a potential therapeutic target for various cancers.

KEYWORDS:

Curcumin; cancer; microRNA; signaling pathway; therapy

PMID:
28222667
DOI:
10.1177/1010428317691680
[Indexed for MEDLINE]

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