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Alzheimers Dement. 2017 Aug;13(8):933-939. doi: 10.1016/j.jalz.2017.01.012. Epub 2017 Feb 21.

Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease.

Author information

1
Department of Biostatistics and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
2
Department of Medicine, University of Washington, Seattle, WA, USA.
3
Department of Epidemiology, University of California, San Francisco, San Francisco, CA, USA.
4
Department of Psychosocial and Community Health, University of Washington, Seattle, WA, USA.
5
Department of Neurology, Swedish Medical Center, Seattle, WA, USA.
6
Group Health Research Institute, Group Health, Seattle, WA, USA.
7
Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: pcrane@uw.edu.

Abstract

INTRODUCTION:

Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.

METHODS:

We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators.

RESULTS:

LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction.

DISCUSSION:

Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.

KEYWORDS:

Ascertainment bias; Bias; Cohort studies; Genetics; Genome-wide association studies; Genome-wide studies; Home research study visits; Inference; Late-onset Alzheimer's disease; Longitudinal studies; Missing data; Population-based studies; Prospective studies; Research clinic study visits; Selection bias

PMID:
28222301
PMCID:
PMC5554082
DOI:
10.1016/j.jalz.2017.01.012
[Indexed for MEDLINE]
Free PMC Article

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