Format

Send to

Choose Destination
Obstet Gynecol Sci. 2017 Jan;60(1):26-31. doi: 10.5468/ogs.2017.60.1.26. Epub 2017 Jan 19.

Endometrial polyp surveillance in premenopausal breast cancer patients using tamoxifen.

Author information

1
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE:

To describe the endometrial pathologic lesions in premenopausal breast cancer patients with a history of tamoxifen (TMX) use.

METHODS:

We retrospectively reviewed the medical records of 120 premenopausal breast cancer patients with a history of TMX use that had undergone a gynecological examination.

RESULTS:

Among 120 patients, 44.2% (n=53) were asymptomatic with an endometrial thickness ≥5 mm, as assessed by transvaginal ultrasonography. Of the patients that reported abnormal uterine bleeding, 5% (n=6) had an endometrial thickness <5 mm and 20% (n=24) had an endometrial thickness ≥5 mm by transvaginal ultrasonography. The final group of patients were asymptomatic, but showed an abnormal endometrial lesion, such as an endometrial polyp, by transvaginal ultrasonography (30.8%, n=37). Of the 56 benign lesions that were histologically reviewed, 50 (41.7%) were endometrial polyps, 3 (2.5%) were submucosal myomas, 2 (1.7%) were endometrial hyperplasias, and 1 (0.8%) was chronic endometritis. There were 64 (53.3%) other non-pathologic conditions, including secreting, proliferative, and atrophic endometrium, or in some cases, there was insufficient material for diagnosis. In our data, only one case was reported as a complex hyperplasia without atypia arising from an endometrial polyp, and one patient was diagnosed with endometrioid adenocarcinoma.

CONCLUSION:

For premenopausal breast cancer patients with a history of TMX use, the majority of the patients were asymptomatic, and endometrial polyps were the most common endometrial pathology observed. Therefore, we believe that endometrial assessment before starting TMX treatment, and regular endometrial screening throughout TMX treatment, are reasonable suggestions for premenopausal breast cancer patients.

KEYWORDS:

Breast neoplasms; Endometrial polyps; Hysteroscopy; Premenopausal; Tamoxifen

Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Supplemental Content

Full text links

Icon for Korean Society of Obstetrics and Gynecology Icon for PubMed Central
Loading ...
Support Center