Send to

Choose Destination
Adv Biomed Res. 2016 Dec 27;5:206. doi: 10.4103/2277-9175.191002. eCollection 2016.

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

Author information

Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.



Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.


Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.


There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, P = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, P = 0.38).


This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.


Desmoglein; pemphigus vulgaris; prolactin

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center