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Indian J Endocrinol Metab. 2017 Jan-Feb;21(1):131-136. doi: 10.4103/2230-8210.196007.

Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency.

Author information

1
Department of Endocrinology, Fortis Escorts Hospital, Amritsar, Punjab, India.
2
Division of Endocrinology and Diabetes, Medanta the Medicity, Gurgaon, Haryana, India.
3
Department of Endocrinology, Indraprastha Apollo Hospitals, New Delhi, India.
4
Senior Consultant Endocrinology and Scientific Advisor (Projects), ILSI-India, New Delhi, India.

Abstract

CONTEXT:

A number of controversies exist regarding appropriate treatment strategy for Vitamin D deficiency.

AIMS:

The aim of this study was to investigate the efficacy of equivalent doses of oral cholecalciferol (60,000 IU weekly for 5 weeks) versus intramuscular (IM) cholecalciferol (300,000 IU) in correcting Vitamin D deficiency in apparently healthy volunteers working in a hospital.

SETTINGS AND DESIGN:

Prospective randomized open-label single institution study.

SUBJECTS AND METHODS:

This study enrolled 40 apparently healthy adults with Vitamin D deficiency into 2 arms. The oral cholecalciferol group (n = 20) received oral cholecalciferol 60,000 IU weekly for 5 weeks while the IM cholecalciferol group (n = 20) received a single injection of cholecalciferol 300,000 IU. The main outcome measure was serum 25-hydroxyvitamin D (25OHD) levels at baseline, 6 and 12 weeks after the intervention.

STATISTICAL ANALYSIS USED:

Differences in serum 25OHD and other biochemical parameters at baseline and follow-up were analyzed using general linear model.

RESULTS:

Mean 25OHD level at baseline was 5.99 ± 1.07 ng/mL and 7.40 ± 1.13 ng/mL (P = 0.332) in the oral cholecalciferol and IM cholecalciferol group, respectively. In the oral cholecalciferol group, serum 25OHD level was 20.20 ± 1.65 ng/mL at 6 weeks and 16.66 ± 1.36 ng/mL at 12 weeks. The corresponding serum 25OHD levels in the IM cholecalciferol group were 20.74 ± 1.81 ng/mL and 25.46 ± 1.37 ng/mL at 6 and 12 weeks, respectively. At 12 weeks, the mean 25OHD levels in IM cholecalciferol group was higher as compared to the oral cholecalciferol group (25.46 ± 1.37 vs. 16.66 ± 1.36 ng/mL; P < 0.001).

CONCLUSIONS:

Both oral and IM routes are effective for the treatment of Vitamin D deficiency. 25-hydroxyvitamin D levels in the IM cholecalciferol group showed a sustained increase from baseline.

KEYWORDS:

Intramuscular cholecalciferol; Vitamin D deficiency; Vitamin D replacement; oral cholecalciferol

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