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Med Gas Res. 2016 Dec 30;6(4):219-222. doi: 10.4103/2045-9912.196904. eCollection 2016 Oct-Dec.

Molecular hydrogen: a therapeutic antioxidant and beyond.

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Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA; Department of Basic Sciences, Division of Physiology, Loma Linda University, Loma Linda, CA, USA.


Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients.


anti-apoptosis; anti-inflammation; biological effect; clinical application; free radical scavenger; hydrogen gas; hydrogen-oxygen nebulizer machine; hydrogen-saturated water/saline

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