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Med Gas Res. 2016 Dec 30;6(4):212-218. doi: 10.4103/2045-9912.196903. eCollection 2016 Oct-Dec.

Application of hyperbaric oxygen in liver transplantation.

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Department of Anaesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Pathology, the First Hospital of Jining City, Jining, Shandong Province, China.
Department of Diving and Hyperbaric Medicine, Secondary Military Medical University, Shanghai, China.


In recent years, hyperbaric oxygen (HBO) has been used in the treatment of a lot of diseases such as decompression sickness, arterial gas embolism, carbon dioxide poisoning, soft tissue infection, refractory osteomyelitis, and problematic wound, but little is known about its application in liver transplantation. Although several studies have been conducted to investigate the protective effects of HBO on liver transplantation and liver preservation, there are still some controversies on this issue, especially its immunomodulatory effect. In this short review, we briefly summarize the findings supporting the application of HBO during liver transplantation (including donors and recipients).


hyperbaric oxygen; immunomodulation; liver ischemia/reperfusion; liver regeneration; liver transplantation; organ preservation; oxidative stress; pre-conditioning

Conflict of interest statement

Conflicts of interest The authors declare that there is no conflict of interest in this paper.

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