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Genome Integr. 2016 Dec 30;7:9. doi: 10.4103/2041-9414.197166. eCollection 2016.

Construction of Calibration Curve for Premature Chromosome Condensation Assay for Dose Assessment.

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1
Laboratory of the Genetical Research and Biodosimetry, Nikiforov Russian Center for Emergency and Radiation Medicine (EMERCOM of Russia), Saint-Petersburg, Russia.

Abstract

Cytogenetic dosimetry plays an important role in the triage and medical management of affected people in radiological incidents/accidents. Cytogenetic biodosimetry uses different methods to estimate the absorbed dose in the exposed individuals, and each approach has its advantages and disadvantages. Premature chromosome condensation (PCC) assay presents several advantages that hopefully fulfill the gaps identified in the other cytogenetic methods. To introduce this technique into the panel of other cytogenetic methods, a calibration curve for PCC after γ-irradiation was generated for our laboratory.

KEYWORDS:

biological dosimetry; calibration curve; premature chromosome condensation; γ-irradiation

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