Format

Send to

Choose Destination
Cancer Lett. 2017 May 1;393:33-39. doi: 10.1016/j.canlet.2017.02.012. Epub 2017 Feb 17.

Targeting autophagy in cancer stem cells as an anticancer therapy.

Author information

1
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
2
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: zhangjianwei_008@126.com.
3
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: shimingyang@yahoo.com.

Abstract

Cancer stem cells (CSCs), which comprise a small proportion of total cancer cells, have special capacities for self-renewal, differentiation and tumor formation. Currently, CSCs are regarded as the major cause of the failure in anticancer therapy, such as chemoresistance and/or radioresistance, tumor recurrence and metastasis. Autophagy, a process of cellular self-digestion and response to stress, has a role in tumor formation and progression, and it may play a dual role in CSCs-related resistance to anticancer therapy. Most researchers believe that autophagy contributes to stemness maintenance of CSCs and is responsible for the failure of anticancer therapy. Unexpectedly, several studies have also suggested that loss of stemness in CSCs could be mediated by autophagy. Here, we review the recent advances in CSCs and autophagy, especially analyze the complex relationship between them, and hope to apply this new knowledge to the strategies for anticancer therapy.

KEYWORDS:

Anticancer therapy; Autophagy; Cancer stem cells; Chemoresistance; Stemness

PMID:
28216370
DOI:
10.1016/j.canlet.2017.02.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center