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Adv Protein Chem Struct Biol. 2017;107:77-115. doi: 10.1016/bs.apcsb.2016.11.006. Epub 2017 Jan 11.

Targeting IKK and NF-κB for Therapy.

Author information

1
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, United States; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States.
2
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States. Electronic address: albert_baldwin@med.unc.edu.

Abstract

In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling.

KEYWORDS:

Cancer; IKK; Inflammation; NF-κB; Therapeutic targets; Transcription factor

PMID:
28215229
DOI:
10.1016/bs.apcsb.2016.11.006
[Indexed for MEDLINE]

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