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Curr Opin Virol. 2017 Apr;23:8-15. doi: 10.1016/j.coviro.2017.01.003. Epub 2017 Feb 17.

Persistent RNA virus infections: do PAMPS drive chronic disease?

Author information

1
Department of Immunology and Microbiology, University of Colorado School of Medicine, USA.
2
Department of Immunology and Microbiology, University of Colorado School of Medicine, USA. Electronic address: thomas.morrison@ucdenver.edu.

Abstract

Chronic disease associated with persistent RNA virus infections represents a key public health concern. While human immunodeficiency virus-1 and hepatitis C virus are perhaps the most well-known examples of persistent RNA viruses that cause chronic disease, evidence suggests that many other RNA viruses, including re-emerging viruses such as chikungunya virus, Ebola virus and Zika virus, establish persistent infections. The mechanisms by which RNA viruses drive chronic disease are poorly understood. Here, we discuss how the persistence of viral RNA may drive chronic disease manifestations via the activation of RNA sensing pathways.

PMID:
28214732
PMCID:
PMC5474173
DOI:
10.1016/j.coviro.2017.01.003
[Indexed for MEDLINE]
Free PMC Article

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