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Curr Opin Cell Biol. 2017 Jun;46:46-53. doi: 10.1016/j.ceb.2017.01.006. Epub 2017 Feb 17.

Dynamic organization of mitotic chromosomes.

Author information

1
Chromosome Dynamics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
2
Chromosome Dynamics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address: hiranot@riken.jp.

Abstract

The assembly of rod-shaped chromosomes during mitosis is an essential prerequisite for faithful segregation of genetic information into daughter cells. Despite the long history of chromosome research, it is only recently that we have acquired powerful approaches and crucial tools that help to unlock the secret of this seemingly complex process. In particular, in vitro assays, mammalian genetics, Hi-C analyses and computer simulations have provided valuable information during the past two years. These studies are now beginning to elucidate how the core components of mitotic chromosomes, namely, histones, topoisomerase IIα and condensins, cooperate with each other to convert very long stretches of DNA into rod-shaped chromosomes.

PMID:
28214612
DOI:
10.1016/j.ceb.2017.01.006
[Indexed for MEDLINE]

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