Characteristics of patients with liver cancer in the BioBank Japan project

Shigekazu Ukawa; Emiko Okada; Koshi Nakamura; Makoto Hirata; Akiko Nagai; Koichi Matsuda; Zentaro Yamagata; Yoichiro Kamatani; Toshiharu Ninomiya; Yutaka Kiyohara; Kaori Muto; Michiaki Kubo; Yusuke Nakamura; BioBank Japan Cooperative Hospital Group; Akiko Tamakoshi

doi:10.1016/j.je.2016.12.007

Characteristics of patients with liver cancer in the BioBank Japan project

J Epidemiol. 2017 Mar;27(3S):S43-S48. doi: 10.1016/j.je.2016.12.007. Epub 2017 Feb 15.

Authors

Collaborators

BioBank Japan Cooperative Hospital Group:
Hiromasa Harada¹⁰, Kiyoshi Kaneko¹⁰, Shuichi Matsumoto¹⁰, Masaki Shiono¹⁰, Shiro Minami¹¹, Hiroshi Yoshida¹¹, Nobuhiko Taniai¹¹, Sumio Watanabe¹², Noriko Fujiwara¹², Atsuyuki Yamataka¹², Satoshi Asai¹³, Mitsuhiko Moriyama¹³, Yasuo Takahashi¹³, Tomoaki Fujioka¹⁴, Wataru Obara¹⁴, Seijiro Mori¹⁵, Hideki Ito¹⁵, Satoshi Nagayama¹⁶, Yoshio Miki¹⁶, Akihide Masumoto¹⁷, Akira Yamada¹⁷, Yasuko Nishizawa¹⁸, Ken Kodama¹⁸, Shigeyuki Naka¹⁹, Yoshihiro Endo¹⁹, Yukihiro Koretsune²⁰, Eiji Mita²⁰, Kozo Morimoto²¹

Affiliations

¹ Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
² Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
³ Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁴ Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁵ Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.
⁶ Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
⁷ Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
⁸ Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
⁹ RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
¹⁰ Tokushukai Hospitals, Japan.
¹¹ Nippon Medical School, Japan.
¹² Juntendo University, Japan.
¹³ Nihon University, Japan.
¹⁴ Iwate Medical University, Japan.
¹⁵ Tokyo Metropolitan Institute of Gerontology, Japan.
¹⁶ The Cancer Institute Hospital of JFCR, Japan.
¹⁷ Aso Iizuka Hospital, Japan.
¹⁸ Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
¹⁹ Shiga University of Medical Science, Japan.
²⁰ National Hospital Organization, Osaka National Hospital, Japan.
²¹ Fukujuji Hospital, Japan.
²² Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Electronic address: tamaa@med.hokudai.ac.jp.

Abstract

Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies.

Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated.

Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the men was overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively.

Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.

Keywords: Cohort; Lifestyle; Liver cancer; Survival rate; Tumor biomarkers.

MeSH terms

Adult
Aged
Aged, 80 and over
Biological Specimen Banks*
Carcinoma, Hepatocellular / diagnosis
Carcinoma, Hepatocellular / mortality
Female
Humans
Japan / epidemiology
Life Style*
Liver Neoplasms / diagnosis*
Liver Neoplasms / mortality*
Male
Middle Aged
Risk Factors
Survival Rate