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J Epidemiol. 2017 Mar;27(3S):S43-S48. doi: 10.1016/j.je.2016.12.007. Epub 2017 Feb 15.

Characteristics of patients with liver cancer in the BioBank Japan project.

Author information

1
Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
2
Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
3
Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
4
Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
5
Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.
6
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
7
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
8
Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
9
RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
10
Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Electronic address: tamaa@med.hokudai.ac.jp.
11
Tokushukai Hospitals, Japan.
12
Nippon Medical School, Japan.
13
Juntendo University, Japan.
14
Nihon University, Japan.
15
Iwate Medical University, Japan.
16
Tokyo Metropolitan Institute of Gerontology, Japan.
17
The Cancer Institute Hospital of JFCR, Japan.
18
Aso Iizuka Hospital, Japan.
19
Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
20
Shiga University of Medical Science, Japan.
21
National Hospital Organization, Osaka National Hospital, Japan.
22
Fukujuji Hospital, Japan.

Abstract

BACKGROUND:

Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies.

METHODS:

Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated.

RESULTS:

Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the men was overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively.

CONCLUSIONS:

The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.

KEYWORDS:

Cohort; Lifestyle; Liver cancer; Survival rate; Tumor biomarkers

PMID:
28214185
PMCID:
PMC5350594
DOI:
10.1016/j.je.2016.12.007
[Indexed for MEDLINE]
Free PMC Article

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