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J Fluency Disord. 2018 Mar;55:46-67. doi: 10.1016/j.jfludis.2017.01.002. Epub 2017 Jan 25.

Anomalous network architecture of the resting brain in children who stutter.

Author information

1
Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States. Electronic address: sooeunc@med.umich.edu.
2
Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States.
3
Department of Communicative Sciences and Disorders, California State University East Bay, Hayward, CA, United States.
4
Department of Psychiatry, University of Utah, Salt Lake City, UT, United States.

Abstract

PURPOSE:

We combined a large longitudinal neuroimaging dataset that includes children who do and do not stutter and a whole-brain network analysis in order to examine the intra- and inter-network connectivity changes associated with stuttering. Additionally, we asked whether whole brain connectivity patterns observed at the initial year of scanning could predict persistent stuttering in later years.

METHODS:

A total of 224 high-quality resting state fMRI scans collected from 84 children (42 stuttering, 42 controls) were entered into an independent component analysis (ICA), yielding a number of distinct network connectivity maps ("components") as well as expression scores for each component that quantified the degree to which it is expressed for each child. These expression scores were compared between stuttering and control groups' first scans. In a second analysis, we examined whether the components that were most predictive of stuttering status also predicted persistence in stuttering.

RESULTS:

Stuttering status, as well as stuttering persistence, were associated with aberrant network connectivity involving the default mode network and its connectivity with attention, somatomotor, and frontoparietal networks. The results suggest developmental alterations in the balance of integration and segregation of large-scale neural networks that support proficient task performance including fluent speech motor control.

CONCLUSIONS:

This study supports the view that stuttering is a complex neurodevelopmental disorder and provides comprehensive brain network maps that substantiate past theories emphasizing the importance of considering situational, emotional, attentional and linguistic factors in explaining the basis for stuttering onset, persistence, and recovery.

KEYWORDS:

Default mode network; Independent component analysis (ICA); Intrinsic connectivity networks; Resting state fMRI; Stuttering

PMID:
28214015
PMCID:
PMC5526749
[Available on 2019-03-01]
DOI:
10.1016/j.jfludis.2017.01.002

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