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Protein Cell. 2017 May;8(5):328-348. doi: 10.1007/s13238-016-0362-6. Epub 2017 Feb 17.

Reprogramming cell fates by small molecules.

Author information

1
Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
2
Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China. saiyong@zju.edu.cn.

Abstract

Reprogramming cell fates towards pluripotent stem cells and other cell types has revolutionized our understanding of cellular plasticity. During the last decade, transcription factors and microRNAs have become powerful reprogramming factors for modulating cell fates. Recently, many efforts are focused on reprogramming cell fates by non-viral and non-integrating chemical approaches. Small molecules not only are useful in generating desired cell types in vitro for various applications, such as disease modeling and cell-based transplantation, but also hold great promise to be further developed as drugs to stimulate patients' endogenous cells to repair and regenerate in vivo. Here we will focus on chemical approaches for generating induced pluripotent stem cells, neurons, cardiomyocytes, hepatocytes and pancreatic β cells. Significantly, the rapid and exciting advances in cellular reprogramming by small molecules will help us to achieve the long-term goal of curing devastating diseases, injuries, cancers and aging.

KEYWORDS:

cell fates; reprogramming; small molecules; stem cells

PMID:
28213718
PMCID:
PMC5413596
DOI:
10.1007/s13238-016-0362-6
[Indexed for MEDLINE]
Free PMC Article

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