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Neuroimage. 2018 Apr 15;170:400-411. doi: 10.1016/j.neuroimage.2017.02.034. Epub 2017 Feb 14.

The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization.

Author information

1
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany. Electronic address: s.genon@fz-juelich.de.
2
Department of Artificial Intelligence, Donders Centre for Cognition, Radboud University Nijmegen, The Netherlands.
3
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
4
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany.
5
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany.
6
Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Germany; Department of Neurology, Cologne University Hospital, Cologne, Germany.
7
Neuroinformatics and Brain Connectivity Lab, Miami, FL, USA.
8
Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX, USA.
9
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

Abstract

Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd.

KEYWORDS:

Precentral gyrus; eye-field; fMRI; meta-analytic connectivity modeling; probabilistic diffusion tractography

PMID:
28213119
PMCID:
PMC5555826
[Available on 2019-04-15]
DOI:
10.1016/j.neuroimage.2017.02.034
[Indexed for MEDLINE]
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