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Mol Cell. 2017 Feb 16;65(4):582-584. doi: 10.1016/j.molcel.2017.02.002.

Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.

Author information

1
Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: rbarran@ncsu.edu.
2
Department of Biomedical Engineering, Center for Genomic & Computational Biology, Duke University, Durham, NC 27708, USA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27708, USA.

Abstract

In this issue of Molecular Cell, Smargon et al. (2017) unearth Cas13b from type VI-B CRISPR-Cas immune systems and characterize its RNA-guided, RNA-targeting activity, including regulation by the novel co-factors Csx27 and Csx28, as well as non-specific collateral RNA damage.

KEYWORDS:

CRISPR; Cas; Cas13b; genome editing

PMID:
28212745
DOI:
10.1016/j.molcel.2017.02.002
[Indexed for MEDLINE]
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