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Elife. 2017 Feb 17;6. pii: e19892. doi: 10.7554/eLife.19892.

Motor control of Drosophila feeding behavior.

Author information

1
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
2
Biozentrum University of Basel, Basel, Switzerland.
3
Division of Zoology and Neurobiology, Technical University Kaiserslautern, Kaiserslautern, Germany.
4
National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, India.

Abstract

The precise coordination of body parts is essential for survival and behavior of higher organisms. While progress has been made towards the identification of central mechanisms coordinating limb movement, only limited knowledge exists regarding the generation and execution of sequential motor action patterns at the level of individual motoneurons. Here we use Drosophila proboscis extension as a model system for a reaching-like behavior. We first provide a neuroanatomical description of the motoneurons and muscles contributing to proboscis motion. Using genetic targeting in combination with artificial activation and silencing assays we identify the individual motoneurons controlling the five major sequential steps of proboscis extension and retraction. Activity-manipulations during naturally evoked proboscis extension show that orchestration of serial motoneuron activation does not rely on feed-forward mechanisms. Our data support a model in which central command circuits recruit individual motoneurons to generate task-specific proboscis extension sequences.

KEYWORDS:

D. melanogaster; feeding behavior; motoneurons; motor circuit; neuroscience

PMID:
28211791
PMCID:
PMC5315463
DOI:
10.7554/eLife.19892
[Indexed for MEDLINE]
Free PMC Article

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