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Int J Pharm Pract. 2017 Dec;25(6):421-428. doi: 10.1111/ijpp.12345. Epub 2017 Feb 17.

A randomized comparative evaluation of clinical and home application to investigate the effectiveness of silver nitrate (AgNO3 ) (95%) for the treatment of verruca pedis.

Author information

1
Division of Podiatry and Clinical Sciences, School of Human and Health Sciences, University of Huddersfield, Huddersfield, West Yorkshire, UK.

Abstract

OBJECTIVE:

To investigate the clinical effectiveness of silver nitrate (95%) for the treatment of verruca pedis comparing professional and self-application treatments.

METHODS:

A single-centre, two-armed randomized evaluation was conducted at a University podiatry clinic. A total of 113 participants (101 analysed) with verruca pedis were included. Participants were randomized to either a clinical group, where silver nitrate was applied by a healthcare professional or a home group, where silver nitrate was self-applied. The main outcome measure was post-treatment pain, controlling for pre-treatment pain, and resolution of the verruca. Secondary outcome measures were participant satisfaction, partial reduction in the verruca and ease of use of the product.

KEY FINDINGS:

The study showed no significant difference between home treatment and clinically applied treatment for the treatment of verruca pedis in either primary outcome; however, a substantive difference in resolution between groups was recorded, with 34.0% full resolution and 26.4% partial resolution in the clinical treatment group, and 18.8% full resolution and 37.5% partial resolution in the home treatment group. Participants widely reported general ease of use of the product. All participants reported a reduction in pain as a result of the intervention.

CONCLUSION:

Silver nitrate has been shown to be a safe and effective treatment for verruca pedis, with equal success rates when compared between home and clinical applications.

KEYWORDS:

randomized evaluation; silver nitrate; verruca pedis; warts

PMID:
28211107
DOI:
10.1111/ijpp.12345
[Indexed for MEDLINE]

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