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J Reward Defic Syndr Addict Sci. 2016;2(1):3-13. doi: 10.17756/jrdsas.2016-022. Epub 2016 May 19.

KB220Z™ a Pro-Dopamine Regulator Associated with the Protracted, Alleviation of Terrifying Lucid Dreams. Can We Infer Neuroplasticity-induced Changes in the Reward Circuit?

Author information

1
Center for Psychiatric Medicine, North Andover, MA, USA.
2
Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
3
Molecular and Functional Imaging Laboratory, Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA; Neuromodulation Program, University of Minnesota Twin City Campus, Minneapolis, MN, USA; Laboratory of Advanced Radiochemistry, University of Minnesota Twin City Campus, Minneapolis, MN, USA.
4
Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, India.
5
Department of Clinical Neurology, PATH Foundation NY, New York, NY, USA.
6
Department of Personalized Medicine, IGENE, LLC., Austin, TX, USA.
7
Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA; Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, India; Department of Clinical Neurology, PATH Foundation NY, New York, NY, USA; Department of Personalized Medicine, IGENE, LLC., Austin, TX, USA; Community Mental Health Institute, Center for Clinical & Translational Science, University of Vermont and Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA; Division of Addiction Services, Dominion Diagnostics, LLC., North Kingstown, RI, USA; Division of Neuroscience-Based Therapy, Summit Estate Recovery Center, Los Gatos, CA, USA; Department of Nutrigenomics, LaVita RDS, LLC, Salt Lake City, UT, USA; Division of Neuroscience Research & Addiction Therapy, Shores Treatment & Recovery Center, Port Saint Lucie, FL, USA; Department of Education & Psychology, Eotvus Lorand University, Budapest, Hungary.

Abstract

BACKGROUND:

Recent reports by our laboratory have indicated that lucid dreams may be linked to psychiatric conditions, including Attention Deficit Hyperactivity Disorder (ADHD) and other Reward Deficiency Syndrome-related diagnoses. In the latter case, it has been our observation that such lucid dreams can be unpleasant and frequently terrifying.

CASE PRESENTATIONS:

We present four cases of a dramatic and persistent alleviation of terrifying, lucid dreams in patients diagnosed with ADHD/PTSD and/or opiate/opioid addiction. The amelioration of such dreams could well be permanent, since the patients had stopped taking the nutraceutical for between 10 to 12 months, without their recollection or recurrence. In the first case, the patient is a 47-year-old, married male who required continued Buprenorphine/ Naloxone (Suboxone) treatment. The second case involved a 32-year-old female with the sole diagnosis of ADHD. The third case involves a 38-year-old male who carried the diagnoses of Substance Use Dependence and ADHD. The fourth case involved a 50-year-old female with the diagnoses of Alcohol Abuse, ADHD and Posttraumatic Stress Disorder.

RESULTS:

In order to attempt to understand the possibility of neuroplasticity, we evaluated the effect of KB220Z in non-opioid-addicted rats utilizing functional Magnetic Resonance Imaging methodology. While we cannot make a definitive claim because rat brain functional connectivity may not be exactly the same as humans, it does provide some interesting clues. We did find following seeding of the dorsal hippocampus, enhanced connectivity volume across several Regions of Interest (ROI), with the exception of the pre- frontal cortex. Interestingly, the latter region is only infrequently activated in lucid human dreaming, when the dreamer reports that he/she had the thought that they were dreaming during the lucid dream.

CONCLUSIONS:

The four patients initially reported a gradual but, then, complete amelioration of their long-term, terrifying, lucid dreams, while taking KB220Z. The persistent amelioration of these dreams continued for up to 12 months, after a self-initiated, cessation of use of KB220Z. These particular cases raise the scientific possibility that KB200Z increases both dopamine stability as well as functional connectivity between networks of brain reward circuitry in both rodents and humans. The increase in connectivity volume in rodents suggest the induction of neuroplasticity changes, which may be analogous to those involved in human lucid dreaming as well as Rapid Eye Movement sleep. The possibility that the complex induces long-term, neuroplasticity changes must await more intensive investigations, involving large-population, double-blinded studies.

KEYWORDS:

Connectivity volume; Dopamine; KB220z; Lucid dreams; Neuroplasticity

Conflict of interest statement

Conflict of Interests Kenneth Blum, PhD, holds US and Foreign patents issued and pending and receives royalties based on its commercialization from various sources. Dr. Blum is also an officer and stockholder of IGENE, LLC., La Vita RDS, LLC., Victory Nutrition, RD Solutions, LLC., and is a paid consultant of Dominion Diagnostics, LLC., Shores Treatment & Recovery Center, and Summit Estate Recovery Program. Dr. Blum is a member of the scientific advisory board of Dominion Diagnostics, LLC., and is their Chief Scientific Advisor. Dr. Blum is a member of the Scientific Advisory Board of Rivermend Health LLC., and Scientific Director of PATH Foundation NY. Margaret A. Madigan is a paid consultant from IGENE, LLC. There are no other conflicts.

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