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Trends Endocrinol Metab. 2017 Apr;28(4):261-272. doi: 10.1016/j.tem.2016.12.005. Epub 2017 Feb 14.

ERRγ: a Junior Orphan with a Senior Role in Metabolism.

Author information

1
National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
2
Department of Molecular Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.
3
National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address: hsc@chonnam.ac.kr.

Abstract

Estrogen-related receptor (ERR)γ is an orphan nuclear hormone receptor that belongs to the ERR subfamily of transcription factors. No endogenous ligand has been identified to date. ERRγ possesses ligand-independent transcriptional activity that is regulated by co-regulator interactions, and post-translational modifications (PTMs). Recent data from animal models have established ERRγ as a crucial mediator of multiple endocrine and metabolic signals. ERRγ plays important roles in pathological conditions such as insulin resistance, alcoholic liver injury, and cardiac hypertrophy, and controls energy metabolism in the heart, skeletal muscle, and pancreatic β cells. These findings corroborate the importance of ERRγ in metabolic homeostasis, and suggest that ERRγ is a good target for the treatment of metabolic diseases.

KEYWORDS:

cell signaling; estrogen-related receptor γ; gene regulation; orphan nuclear receptor

PMID:
28209382
DOI:
10.1016/j.tem.2016.12.005
[Indexed for MEDLINE]

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