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Molecules. 2017 Feb 12;22(2). pii: E275. doi: 10.3390/molecules22020275.

Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana.

Author information

1
Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. asthagiri.herbal@gmail.com.
2
Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. mahesh7605@yahoo.co.in.
3
Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666 Sharjah, United Arab Emirates. iabuyousef@aus.edu.
4
Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666 Sharjah, United Arab Emirates. amajdalawieh@aus.edu.
5
Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. rethavathij@gmail.com.
6
Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. prince.ahrf@gmail.com.
7
Institute of Sciences of Food Productions, CNR-ISPA, Lecce 73100, Italy. palmiro.poltronieri@ispa.cnr.it.

Abstract

The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.

KEYWORDS:

anti-bacterial; anti-fungal; biomedical device; packaging; semi-synthetic modification; textiles; α-mangostin

PMID:
28208680
PMCID:
PMC6155947
DOI:
10.3390/molecules22020275
[Indexed for MEDLINE]
Free PMC Article

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