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Org Lett. 2017 Mar 3;19(5):1000-1003. doi: 10.1021/acs.orglett.6b03831. Epub 2017 Feb 16.

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.

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Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute , 07745 Jena, Germany.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.
Natural Product Research Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
Department of Molecular & Cell Biology, University of Connecticut , Storrs, Connecticut 06269, United States.
Daniel K. Inouye College of Pharmacy, University of Hawaii , Hilo, Hawaii 96720, United States.
Centre for Social Evolution, Section for Ecology and Evolution, Department of Biology, University of Copenhagen , 2100 Copenhagen East, Denmark.


Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

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