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J Perinatol. 2017 Jun;37(6):658-661. doi: 10.1038/jp.2017.8. Epub 2017 Feb 16.

Defining the limitations of transcutaneous bilirubin measurement in late preterm newborns.

Author information

1
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
2
Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA.
3
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Abstract

OBJECTIVE:

The objective of this study is to determine the impact of postnatal age on the bias between transcutaneous (TcB) and total serum bilirubin (TSB), and evaluate a TcB screening protocol.

STUDY DESIGN:

Preterm and term infants had paired TcB and TSB performed on days 1 to 3 of life; a subset of preterm infants had measurements on days 4 to 7. Sensitivity and specificity of TcB (plotted on an age-specific TSB nomogram) for prediction of high-intermediate (HIR) or high-risk TSB were calculated.

RESULTS:

Median TcB bias was 2.6 and 2.5 mg dl-1 for term and preterm infants in the first 3 days of life, respectively. However, median bias was 2.2 mg dl-1 for preterm infants at 4 to 7 days of life. TcB in preterm infants predicted HIR or high-risk TSB with 94% sensitivity and 56% specificity.

CONCLUSION:

TcB screening protocols developed for term infants can be used for late preterm infants in the first 3 days of life.

PMID:
28206994
DOI:
10.1038/jp.2017.8
[Indexed for MEDLINE]

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