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Sci Rep. 2017 Feb 13;7:42346. doi: 10.1038/srep42346.

HRGFish: A database of hypoxia responsive genes in fishes.

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Molecular Biology and Biotechnology Division, ICAR- National Bureau of Fish Genetic Resources, Lucknow- 226002, Uttar Pradesh, India.
AMITY Institute of Biotechnology, AMITY University Uttar Pradesh, Lucknow-226028, Uttar Pradesh, India.
Fish Genetics and Biotechnology Division, ICAR- Central Institute of Fisheries Education, Mumbai-400 061, Maharashtra, India.


Several studies have highlighted the changes in the gene expression due to the hypoxia response in fishes, but the systematic organization of the information and the analytical platform for such genes are lacking. In the present study, an attempt was made to develop a database of hypoxia responsive genes in fishes (HRGFish), integrated with analytical tools, using LAMPP technology. Genes reported in hypoxia response for fishes were compiled through literature survey and the database presently covers 818 gene sequences and 35 gene types from 38 fishes. The upstream fragments (3,000 bp), covered in this database, enables to compute CG dinucleotides frequencies, motif finding of the hypoxia response element, identification of CpG island and mapping with the reference promoter of zebrafish. The database also includes functional annotation of genes and provides tools for analyzing sequences and designing primers for selected gene fragments. This may be the first database on the hypoxia response genes in fishes that provides a workbench to the scientific community involved in studying the evolution and ecological adaptation of the fish species in relation to hypoxia.

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