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J Am Geriatr Soc. 2017 May;65(5):1067-1072. doi: 10.1111/jgs.14779. Epub 2017 Feb 15.

Multicenter Validation of an MMSE-MoCA Conversion Table.

Author information

1
Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques du CHU de Québec, and Faculté de Médecine, Université Laval, Québec, Québec, Canada.
2
University of British Columbia, Vancouver, British Columbia, Canada.
3
Division of Neurology, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
4
Alzheimer's Disease Research Unit/Memory Clinic, McGill Centre for Studies in Aging, Montreal, Quebec, Canada.
5
Neuro Rive-Sud/CEDRA: Centre Diagnostique et Recherche sur la Maladie d'Alzheimer, McGill University and Sherbrooke University, Montréal, Quebec, Canada.

Abstract

BACKGROUND:

Accumulating evidence points to the superiority of the MoCA over the MMSE as a cognitive screening tool. To facilitate the transition from the MMSE to the MoCA in clinical and research settings, authors have developed MMSE-MoCA conversion tables. However, it is unknown whether a conversion table generated from Alzheimer's disease (AD) patients would apply to patients with other dementia subtypes like vascular dementia or frontotemporal dementia. Furthermore, the reliability and accuracy of MMSE-MoCA conversion tables has not been properly evaluated.

METHOD:

We retrospectively examined the MMSE-MoCA relationship in a large multicenter sample gathered from 3 Memory Clinics in Quebec, Canada (1492 patients). We produced an MMSE-MoCA conversion table using the equi-percentile method with log-linear smoothing. We then cross-validated our conversion table with the ADNI dataset (1202 patients) and evaluated its accuracy for future predictions.

RESULTS:

The MMSE-MoCA conversion table is consistent with previously published tables and has an intra-class correlation of 0.633 with the ADNI sample. However, we found that the MMSE-MoCA relationship is significantly modified by diagnosis (P < .01), with dementia subtypes associated with a dysexecutive syndrome showing a trend towards higher MMSE than other dementia syndromes for a given MoCA score. The large width of 95% confidence interval (CI) for a new prediction suggests questionable reliability for clinical use.

CONCLUSION:

In this study, we validated a conversion table between MMSE and MoCA using a large multicenter sample. Our results suggest caution in interpreting the tables in heterogeneous clinical populations, as the MMSE-MoCA relationship may be different across dementia subtypes.

KEYWORDS:

MMSE ; Cognitive screening; Conversion; MoCA

PMID:
28205215
DOI:
10.1111/jgs.14779
[Indexed for MEDLINE]

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