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Arch Virol. 2017 Jun;162(6):1725-1730. doi: 10.1007/s00705-017-3276-6. Epub 2017 Feb 15.

Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children.

Kwak BO1,2, Lee HJ1,3, Kang HM1,3, Oh CE4, Choi EH5,6.

Author information

1
Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
2
Department of Microbiology, Konkuk University School of Medicine, Seoul, Korea.
3
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
4
Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.
5
Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea. eunchoi@snu.ac.kr.
6
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. eunchoi@snu.ac.kr.

Abstract

This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. A genotype analysis of ORF 22 amino acids revealed genotype J in all children except one. Genotype E was identified in an infant with varicella imported from Egypt.

KEYWORDS:

Children; Genotype; Varicella-zoster virus

PMID:
28204894
DOI:
10.1007/s00705-017-3276-6
[Indexed for MEDLINE]

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