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J Orthop. 2017 Feb 3;14(2):223-225. doi: 10.1016/j.jor.2017.01.003. eCollection 2017 Jun.

Transplantation of autologous chondrocytes ex-vivo expanded using Thermoreversible Gelation Polymer in a rabbit model of articular cartilage defect.

Author information

1
Sri Ramachandra Arthroscopy & Sports Sciences Centre (SRASSC), Sri Ramachandra University, Chennai, India.
2
Mebiol Inc., Hiratsuka, Japan.
3
The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India.
4
The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India; Hope Foundation (Trust), Chennai, India.
5
The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India; II Department of Surgery, Yamanashi University- School of Medicine, Chuo, Japan.

Abstract

Graft failure due to de-differentiation of the chondrocytes during in vitro culture and after transplantation is a major hurdle in Autologous Chondrocyte Implantation (ACI). We, herein, report the transplantation of autologous chondrocytes ex vivo expanded using a Thermo-reversible Gelation Polymer (TGP) in a rabbit model. A full thickness chondral defect was created in one of the knee joints in each of the six rabbits of the study and autologous chondrocytes in vitro expanded using TGP scaffold were transplanted after 10 weeks. H & E staining of the biopsy after 6 months revealed maintenance of articular cartilage phenotype.

KEYWORDS:

Articular cartilage; Autologous chondrocyte implantation (ACI); De-differentiation; Thermo-reversible gelation polymer (TGP); Tissue engineering

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